Dynamics and ecological reassembly of the human gut microbiome and the host metabolome in response to prolonged fasting.

ABSTRACT:

Introduction

Prolonged fasting is an intervention approach with potential benefits for individuals with obesity or metabolic disorders. Changes in gut microbiota during and after fasting may also have significant effects on the human body.

Methods

Here we conducted a 7-days medically supervised water-only fasting for 46 obese volunteers and characterized their gut microbiota based on whole-metagenome sequencing of feces at five timepoints.

Results

Substantial changes in the gut microbial diversity and composition were observed during fasting, with rapid restoration after fasting. The ecological pattern of the microbiota was also reassembled during fasting, reflecting the reduced metabolic capacity of diet-derived carbohydrates, while other metabolic abilities such as

SUBMITTER: Sang X 

PROVIDER: S-EPMC10579591 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature