Identification of an APOE ε4-specific blood-based molecular pathway for Alzheimer's disease risk.

ABSTRACT:

Introduction

The precise apolipoprotein E (APOE) ε4-specific molecular pathway(s) for Alzheimer's disease (AD) risk are unclear.

Methods

Plasma protein modules/cascades were analyzed using weighted gene co-expression network analysis (WGCNA) in the Alzheimer's Disease Neuroimaging Initiative study. Multivariable regression analyses were used to examine the associations among protein modules, AD diagnoses, cerebrospinal fluid (CSF) phosphorylated tau (p-tau), and brain glucose metabolism, stratified by APOE genotype.

Results

The Green Module was associated with AD diagnosis in APOE ε4 homozygotes. Three proteins from this module, C-reactive protein (CRP), complement C3, and complement factor H (CFH), had dose-dependent associations with CSF p-tau a

SUBMITTER: Tao Q 

PROVIDER: S-EPMC10579631 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature