Similarities and differences in gene expression profiles of BRCA1 methylated and mutated epithelial ovarian cancers.

ABSTRACT:

Introduction

BRCA1 methylated (BRCA1^met) epithelial ovarian cancer (EOC) is a recently defined and not well-investigated subset of neoplasms. To date, no studies have focused on the transcriptional profiles of BRCA1^met cases, and, as a matter of fact, we still do not know if this subset of EOCs is similar, and to what extent, to BRCA1 mutated (BRCA1^mut) cases.

Methods

We compared a group of 17 BRCA1^met cases against 10 BRCA1^mut cases using a subset of carefully selected 17 BRCA^wt EOCs as a control group.

Results

First, BRCA1^met cases showed a downregulation of the relative transcript, while this association was not observed for

SUBMITTER: Sahnane N 

PROVIDER: S-EPMC10579792 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature