PSGL-1: a novel immune checkpoint driving T-cell dysfunction in obstructive sleep apnea.

ABSTRACT:

Introduction

Although higher incidence of cancer represents a major burden for obstructive sleep apnea (OSA) patients, the molecular pathways driving this association are not completely understood. Recently, the adhesion receptor P-selectin glycoprotein-1 (PSGL 1) has been identified as a novel immune checkpoint, which are recognized major hallmarks in several types of cancer and have revolutionized cancer therapy.

Methods

The expression of PSGL-1 and its ligands VISTA and SIGLEC-5 was assessed in the leucocytes of OSA patients and control subjects exploring the role of intermittent hypoxia (IH) using in vitro models. In addition, PSGL-1 impact on T-cells function was evaluated by ex vivo models.

Results

Data showed PSGL-1 expression is upregulated in th

SUBMITTER: Diaz-Garcia E 

PROVIDER: S-EPMC10579800 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature