Development and validation of diagnostic and activity-assessing models for relapsing polychondritis based on laboratory parameters.

ABSTRACT:

Background

Relapsing polychondritis (RP) as a rare autoimmune disease is characterized by recurrent inflammation of the organs containing cartilage. Currently, no biomarkers have been integrated into clinical practice. This study aimed to construct and evaluate models based on laboratory parameters to aid in RP diagnosis, assess activity assessment, and explore associations with the pathological process.

Methods

RP patients and healthy controls (HCs) were recruited at the Peking Union Medical College Hospital from July 2017 to July 2023. Clinical data including Relapsing Polychondritis Disease Activity Index (RPDAI) score and laboratory tests were collected. Differences in laboratory data between RP patients and HCs and active and inactive patients were analyzed.

Results<

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10579920 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature