Gut microbiota-bile acid-vitamin D axis plays an important role in determining oocyte quality and embryonic development.

ABSTRACT:

Objective

To reveal whether gut microbiota and their metabolites are correlated with oocyte quality decline caused by circadian rhythm disruption, and to search possible approaches for improving oocyte quality.

Design

A mouse model exposed to continuous light was established. The oocyte quality, embryonic development, microbial metabolites and gut microbiota were analyzed. Intragastric administration of microbial metabolites was conducted to confirm the relationship between gut microbiota and oocyte quality and embryonic development.

Results

Firstly, we found that oocyte quality and embryonic development decreased in mice exposed to continuous light. Through metabolomics profiling and 16S rDNA-seq, we found that the intestinal absorption capacity of vitamin D was decr

SUBMITTER: Li A 

PROVIDER: S-EPMC10580005 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature