Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease.

ABSTRACT:

Importance

Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains unclear whether increased WMH along the AD continuum is reflective of AD-intrinsic processes or secondary to elevated systemic vascular risk factors.

Objective

To estimate the associations of neurodegeneration and parenchymal and vessel amyloidosis with WMH accumulation and investigate whether systemic vascular risk is associated with WMH beyond these AD-intrinsic processes.

Design, setting, and participants

This cohort study used data from 3 longitudinal cohort studies conducted in tertiary and community-based medical centers-the Dominantly Inherit

SUBMITTER: Shirzadi Z 

PROVIDER: S-EPMC10580156 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature