Phthalate mixtures and insulin resistance: an item response theory approach to quantify exposure burden to phthalate mixtures.

ABSTRACT:

Background

Molar sums are often used to quantify total phthalate exposure, but they do not capture patterns of exposure to multiple phthalates.

Objective

To introduce an exposure burden score method for quantifying exposure to phthalate metabolites and examine the association between phthalate burden scores and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR).

Methods

We applied item response theory (IRT) to data from 3474 adults aged 20-60 years in the 2013-2018 National Health and Examination Survey (NHANES) to quantify latent phthalate exposure burden from 12 phthalate metabolites. We compared model fits of three IRT models that used different a priori groupings (general phthalate burden; low molecular weight (LMW) and high molecular weight (HMW) burde

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10580272 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature