Delayed CO₂ postconditioning promotes neurological recovery after cryogenic traumatic brain injury by downregulating IRF7 expression.

ABSTRACT:

Aims

Few treatments are available in the subacute phase of traumatic brain injury (TBI) except rehabilitation training. We previously reported that transient CO₂ inhalation applied within minutes after reperfusion has neuroprotective effects against cerebral ischemia/reperfusion injury. In this study, it was hypothesized that delayed CO₂ postconditioning (DCPC) starting at the subacute phase may promote neurological recovery of TBI.

Methods

Using a cryogenic TBI (cTBI) model, mice received DCPC daily by inhaling 5%/10%/20% CO₂ for various time-courses (one/two/three cycles of 10-min inhalation/10-min break) at Days 3-7, 3-14 or 7-18 after cTBI. Beam walking and gait tests were used to assess the effect of DCPC. Lesion size, expression of GAP-

SUBMITTER: Li Y 

PROVIDER: S-EPMC10580333 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature