Hypericin as a potential drug for treating Alzheimer's disease and type 2 diabetes with a view to drug repositioning.

ABSTRACT:

Aims

Alzheimer's disease (AD) and type 2 diabetes (T2D) are two of the most common diseases in elderly population and they have a high rate of comorbidity. Study has revealed that T2D is a major risk factor of AD, and thus exploring therapeutic approaches that can target both diseases has drawn much interest in recent years. In this study, we tried to explore drugs that could be potentially used to prevent or treat both AD and T2D via a drug repositioning approach.

Methods

We first searched the known drugs that may be effective to T2D treatment based on the network distance between the T2D-associated genes and drugs deposited in the DrugBank database. Then, via molecular docking, we further screened these drugs by examining their interaction with islet amyloid polypeptide (I

SUBMITTER: Yuan X 

PROVIDER: S-EPMC10580347 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature