HOXD-AS2-STAT3 feedback loop attenuates sensitivity to temozolomide in glioblastoma.

ABSTRACT:

Aims

Glioblastoma multiforme (GBM) is the deadliest glioma and its resistance to temozolomide (TMZ) remains intractable. Long non-coding RNAs (lncRNAs) play crucial roles in that and this study aimed to investigate underlying mechanism of HOXD-AS2-affected temozolomide sensitivity in glioblastoma.

Methods

We analyzed and validated the aberrant HOXD-AS2 expression in glioma specimens. Then we explored the function of HOXD-AS2 in vivo and in vitro and a clinical case was also reviewed to examine our findings. We further performed mechanistic experiments to investigate the mechanism of HOXD-AS2 in regulating TMZ sensitivity.

Results

Elevated HOXD-AS2 expression promoted progression and negatively correlated with prognosis of glioma; HOXD-AS2 attenuated temozolomide sensi

SUBMITTER: Zhang ZX 

PROVIDER: S-EPMC10580348 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature