Dataset Information

Altered gray-to-white matter tissue contrast in preterm-born adults.

ABSTRACT:

Aims

To investigate cortical organization in brain magnetic resonance imaging (MRI) of preterm-born adults using percent contrast of gray-to-white matter signal intensities (GWPC), which is an in vivo proxy measure for cortical microstructure.

Methods

Using structural MRI, we analyzed GWPC at different percentile fractions across the cortex (0%, 10%, 20%, 30%, 40%, 50%, and 60%) in a large and prospectively collected cohort of 86 very preterm-born (<32 weeks of gestation and/or birth weight <1500 g, VP/VLBW) adults and 103 full-term controls at 26 years of age. Cognitive performance was assessed by full-scale intelligence quotient (IQ) using the Wechsler Adult Intelligence Scale.

Results

GWPC was significantly decreased in VP/VLBW adults in frontal, parietal, and temporal associative cortices, predominantly in the right hemisphere. Differences were pronounced at 20%, 30%, and 40%, hence, in middle cortical layers. GWPC was significantly increased in right paracentral lobule in VP/VLBW adults. GWPC in frontal and temporal cortices was positively correlated with birth weight, and negatively with duration of ventilation (p < 0.05). Furthermore, GWPC in right paracentral lobule was negatively correlated with IQ (p < 0.05).

Conclusions

Widespread aberrant gray-to-white matter contrast suggests lastingly altered cortical microstructure after preterm birth, mainly in middle cortical layers, with differential effects on associative and primary cortices.

SUBMITTER: Schmitz-Koep B

PROVIDER: S-EPMC10580354 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Altered gray-to-white matter tissue contrast in preterm-born adults.

Schmitz-Koep Benita B Menegaux Aurore A Zimmermann Juliana J Thalhammer Melissa M Neubauer Antonia A Wendt Jil J Schinz David D Daamen Marcel M Boecker Henning H Zimmer Claus C Priller Josef J Wolke Dieter D Bartmann Peter P Sorg Christian C Hedderich Dennis M DM

CNS neuroscience & therapeutics 20230627 11

<h4>Aims</h4>To investigate cortical organization in brain magnetic resonance imaging (MRI) of preterm-born adults using percent contrast of gray-to-white matter signal intensities (GWPC), which is an in vivo proxy measure for cortical microstructure.<h4>Methods</h4>Using structural MRI, we analyzed GWPC at different percentile fractions across the cortex (0%, 10%, 20%, 30%, 40%, 50%, and 60%) in a large and prospectively collected cohort of 86 very preterm-born (<32 weeks of gestation and/or bi ...[more]

PMID: 37365964

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Dataset Information

Altered gray-to-white matter tissue contrast in preterm-born adults.

Aims

Methods

Results

Conclusions

Publications

Altered gray-to-white matter tissue contrast in preterm-born adults.

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