FHOD1 is upregulated in glioma cells and attenuates ferroptosis of glioma cells by targeting HSPB1 signaling.

ABSTRACT:

Background

As a new type of regulatory cell death, ferroptosis has been proven to be involved in cancer pathogenesis and therapeutic response. However, the detailed roles of ferroptosis or ferroptosis-associated genes in glioma remain to be clarified.

Methods

Here, we performed the TMT/iTRAQ-Based Quantitative Proteomic Approach to identify the differentially expressed proteins between glioma specimens and adjacent tissues. Kaplan-Meier survival was used to estimate the survival values. We also explored the regulatory roles of abnormally expressed formin homology 2 domain-containing protein 1 (FHOD1) in glioma ferroptosis sensitivity.

Results

In our study, FHOD1 was identified to be the most significantly upregulated protein in glioma tissues. Multiple glioma datasets

SUBMITTER: Zhang F 

PROVIDER: S-EPMC10580363 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature