Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infections.

ABSTRACT:

Background

Bats harbor various viruses without severe symptoms and act as their natural reservoirs. The tolerance of bats against viral infections is assumed to originate from the uniqueness of their immune system. However, how immune responses vary between primates and bats remains unclear. Here, we characterized differences in the immune responses by peripheral blood mononuclear cells to various pathogenic stimuli between primates (humans, chimpanzees, and macaques) and bats (Egyptian fruit bats) using single-cell RNA sequencing.

Results

We show that the induction patterns of key cytosolic DNA/RNA sensors and antiviral genes differed between primates and bats. A novel subset of monocytes induced by pathogenic stimuli specifically in bats was identified. Furthermore, bats r

SUBMITTER: Aso H 

PROVIDER: S-EPMC10580374 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature