The Many Faces of Histidine Triad Nucleotide Binding Protein 1 (HINT1).

ABSTRACT: The histidine triad nucleotide binding protein 1 (HINT1) is a nucleoside phosphoramidase that has garnered interest due to its widespread expression and participation in a broad range of biological processes. Herein, we discuss the role of HINT1 as a regulator of several CNS functions, tumor suppressor, and mast cell activator via its interactions with multiple G-protein-coupled receptors and transcription factors. Importantly, altered HINT1 expression and mutation are connected to the progression of multiple disease states, including several neuropsychiatric disorders, peripheral neuropathy, and tumorigenesis. Additionally, due to its involvement in the activation of several clinically used phosphoramidate prodrugs, tremendous efforts have been made to better understand the interactions b

SUBMITTER: Dillenburg M 

PROVIDER: S-EPMC10580397 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature