Differential expression of zinc finger CCHC-type superfamily proteins in thyroid carcinoma and their associations with tumor immunity.

ABSTRACT:

Background

The zinc-finger CCHC-type (ZCCHC) superfamily proteins are characterized by the shared sequence CX2-CX4-HX4-C and thought to own high affinity to single-stranded nucleic acids, particularly RNAs. In humans, a total of 24 ZCCHC proteins have been annotated in the HUGO Gene Nomenclature Committee (HGNC, https://www.genenames.org/ ) database with most of these members involved in multiple steps of RNA metabolism. Many studies have indicated that the ZCCHC genes play a regulatory role in the development and progression of solid tumors. To date, the expression pattern and prognostic value of ZCCHC factors in thyroid carcinomas have not been reported.

Methods

Bioinformatics analyses on the functions of ZCCHC factors in thyroid carcinoma (THCA) patients were performed ba

SUBMITTER: Yin Y 

PROVIDER: S-EPMC10580525 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature