Differential transcriptome response following infection of porcine ileal enteroids with species A and C rotaviruses.

ABSTRACT:

Background

Rotavirus C (RVC) is the major causative agent of acute gastroenteritis in suckling piglets, while most RVAs mostly affect weaned animals. Besides, while most RVA strains can be propagated in MA-104 and other continuous cell lines, attempts to isolate and culture RVC strains remain largely unsuccessful. The host factors associated with these unique RVC characteristics remain unknown.

Methods

In this study, we have comparatively evaluated transcriptome responses of porcine ileal enteroids infected with RVC G1P[1] and two RVA strains (G9P[13] and G5P[7]) with a focus on innate immunity and virus-host receptor interactions.

Results

The analysis of differentially expressed genes regulating antiviral immune response indicated that in contrast to RVA, RVC infecti

SUBMITTER: Raev SA 

PROVIDER: S-EPMC10580564 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature