Association between gut microbiota and influenza: a bidirectional two-sample mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have indicated a correlation between the gut microbiota and influenza; however, the exact nature of the bidirectional causal connection remains uncertain.

Method

A two-way, two-sample Mendelian randomization (MR) study was conducted to evaluate the possible causal connection between the gut microbiota and the two outcomes of influenza (pneumonia without influenza and influenza pneumonia). The statistical analysis of gut microbiota is derived from the information of the most extensive meta-analysis (GWAS) conducted by the MiBioGen Alliance, encompassing a sample size of 18,340.The summary statistical data for influenza (not pneumonia, n = 291,090) and influenza pneumonia (n = 342,499) are from GWAS data published by FinnGen consortium

SUBMITTER: Xu F 

PROVIDER: S-EPMC10580584 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature