Perinatal folate levels do not influence tumor latency or multiplicity in a model of NF1 associated plexiform-like neurofibromas.

ABSTRACT:

Objective

In epidemiological and experimental research, high folic acid intake has been demonstrated to accelerate tumor development among populations with genetic and/or molecular susceptibility to cancer. Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder predisposing affected individuals to tumorigenesis, including benign plexiform neurofibromas; however, understanding of factors associated with tumor risk in NF1 patients is limited. Therefore, we investigated whether pregestational folic acid intake modified plexiform-like peripheral nerve sheath tumor risk in a transgenic NF1 murine model.

Results

We observed no significant differences in overall survival according to folate group. Relative to controls (180 days), median survival did not statisticall

SUBMITTER: Williams KB 

PROVIDER: S-EPMC10580592 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature