A prospective, observational study of frailty, quality of life and dialysis in older people with advanced chronic kidney disease.

ABSTRACT:

Background

Frailty is prevalent in older people with chronic kidney disease (CKD) and robust evidence supporting the benefit of dialysis in this setting is lacking. We aimed to measure frailty and quality of life (QOL) longitudinally in older people with advanced CKD and assess the impact of dialysis initiation on frailty, QOL and mortality.

Methods

Outpatients aged ≥65 with an eGFR ≤ 20ml/minute/1.73m² were enrolled in a prospective observational study and followed up four years later. Frailty status was measured using a Frailty Index (FI), and QOL was evaluated using the EuroQol 5D-5L instrument. Mortality and dialysis status were determined through inspection of electronic records.

Results

Ninety-eight participants were enrolled. Between enrolment and fo

SUBMITTER: King SJ 

PROVIDER: S-EPMC10580596 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature