Interactions of platelets with obesity in relation to lung cancer risk in the UK Biobank cohort.

ABSTRACT:

Background

Platelet count (PLT) is associated positively with lung cancer risk but has a more complex association with body mass index (BMI), positive only in women (mainly never smokers) and inverse in men (mainly ever smokers), raising the question whether platelets interact with obesity in relation to lung cancer risk. Prospective associations of platelet size (an index of platelet maturity and activity) with lung cancer risk are unclear.

Methods

We examined the associations of PLT, mean platelet volume (MPV), and platelet distribution width (PDW) (each individually, per one standard deviation increase) with lung cancer risk in UK Biobank men and women using multivariable Cox proportional hazards models adjusted for BMI and covariates. We calculated Relative Excess Risk f

SUBMITTER: Christakoudi S 

PROVIDER: S-EPMC10580651 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature