α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis.

ABSTRACT: The major neuropathologic feature of Parkinson's disease is the presence of widespread intracellular inclusions of α-synuclein known as Lewy bodies. Evidence suggests that these misfolded protein inclusions spread through the brain with disease progression. Changes in synaptic function precede neurodegeneration, and this extracellular α-synuclein can affect synaptic transmission. However, whether and how the spreading of α-synuclein aggregates modulates synaptic function before neuronal loss remains unknown. In the present study, we investigated the effect of intrastriatal injection of α-synuclein preformed fibrils (PFFs) on synaptic activity in the somatosensory cortex using a combination of whole-cell patch-clamp electrophysiology, histology, and Golgi-Cox staining. Intrastriatal PFF inj

SUBMITTER: Perez-Acuna D 

PROVIDER: S-EPMC10580656 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature