Inflammatory Markers in Mother's Own Milk and Infant Stool of Very Low Birthweight Infants.

ABSTRACT:

Background

Mother's breastmilk is the gold standard for feeding preterm infants. Preterm delivery may be precipitated by inflammatory maternal states, but little is known about milk cytokine profiles and how they correlate with markers of infant gut inflammation (i.e., stool calprotectin) in this vulnerable population.

Research aim

To assess cytokines and inflammatory markers in milk from parents of very preterm infants over time as well as correlations between milk and infant's stool calprotectin.

Method

This is a secondary analysis of milk samples collected during OptiMoM, a triple-blind randomized clinical trial of infants born < 1250 g (NCT02137473). Longitudinally collected samples were analyzed for cytokines, choline, and inflammatory markers (C-reactive protein

SUBMITTER: Hoban R 

PROVIDER: S-EPMC10580668 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature