Advanced Glycation End Products and Inflammatory Cytokine Profiles in Maintenance Hemodialysis Patients After the Ingestion of a Protein-Dense Meal.

ABSTRACT:

Objective

The goal of this investigation was to evaluate circulating and skeletal muscle inflammatory biomarkers between maintenance hemodialysis (MHD) and demographic-matched control subjects (CON) before and after ingestion of a protein-rich meal.

Design and methods

CON (n = 8; 50 ± 2 years; 31 ± 1 kg/m²) and MHD patients (n = 8; 56 ± 5 years; 32 ± 2 kg/m²) underwent a basal blood draw and muscle biopsy and serial blood draws after the ingestion of a mixed meal on a nondialysis day. Plasma advanced glycation end products (AGEs) and markers of oxidation were assessed via liquid chromatography-tandem mass spectrometry before and after the meal (+240 min). Circulating inflammatory cytokines and soluble receptors for AGE (sRAGE) isoforms (endogenous secre

SUBMITTER: Perkins RK 

PROVIDER: S-EPMC10580815 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature