Composition and functional profiles of gut microbiota reflect the treatment stage, severity, and etiology of acute pancreatitis.

ABSTRACT: Acute pancreatitis (AP) is a type of digestive system disease with high mortality. Previous studies have shown that gut microbiota can participate in developing and treating acute pancreatitis by affecting the host's metabolism. In this study, we followed 20 AP patients to generate longitudinal gut microbiota profiles and activity during disease (before treatment, on the third day of treatment, and 1 month after discharge). We analyzed species composition and metabolic pathways' changes across the treatment phase, severity, and etiology. The diversity of the gut microbiome of patients with AP did not show much variation with treatment. In contrast, the metabolic functions of the gut microbiota, such as the essential chemical reactions that produce energy and maintain life, were partially r

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10580821 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature