Emergence of cryptic species and clades of <i>Meyerozyma guilliermondii</i> species complex exhibiting limited <i>in vitro</i> susceptibility to antifungals in patients with candidemia.

ABSTRACT: Members of the Meyerozyma guilliermondii species complex are able to cause superficial and life-threatening systemic infections with low susceptibility to azoles and echinocandins. We tested 130 bloodstream M. guilliermondii complex isolates collected from eight Latin American medical centers over 18 years (period 1 = 2000-2008 and period 2 = 2009-2018) to investigate trends in species distribution and antifungal resistance. The isolates were identified by rDNA ITS region sequencing, and antifungal susceptibility tests were performed against fluconazole, voriconazole, anidulafungin, and amphotericin B using the CLSI microbroth method. M. guilliermondii sensu stricto (s.s.; n = 116) was the most prevalent species, followed by Meyerozyma caribbica (n

SUBMITTER: Francisco EC 

PROVIDER: S-EPMC10580822 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature