SARS-CoV-2 infection severity and mortality is modulated by repeat-mediated regulation of alternative splicing.

ABSTRACT: Like single-stranded RNA viruses, SARS-CoV-2 hijacks the host transcriptional machinery for its own replication. Numerous traditional differential gene expression-based investigations have examined the diverse clinical symptoms caused by SARS-CoV-2 infection. The virus, on the other hand, also affects the host splicing machinery, causing host transcriptional dysregulation, which can lead to diverse clinical outcomes. Hence, in this study, we performed host transcriptome sequencing of 125 hospital-admitted COVID-19 patients to understand the transcriptomic differences between the severity sub-phenotypes of mild, moderate, severe, and mortality. We performed transcript-level differential expression analysis, investigated differential isoform usage, looked at the splicing patterns within the

SUBMITTER: Mehta P 

PROVIDER: S-EPMC10580830 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature