Lugdunin production and activity in Staphylococcus lugdunensis isolates are associated with its genotypes.

ABSTRACT: Lugdunin produced by Staphylococcus lugdunensis has been shown to have broad inhibitory activity against Gram-positive bacteria; however, lugdunin activity among S. lugdunensis isolates and its association with different agr, SCCmec, and sequence types remain unclear. We used matrix-assisted laser desorption ionization-time-of-flight mass spectrometry to identify S. lugdunensis and collected 202 S. lugdunensis samples for further assays. Agar spot tests were performed to characterize S. lugdunensis lugdunin production and activity. Multilocus sequence typing, SCCmec, and agr genotyping were performed on S. lugdunensis. In all, 91 Staphylococcus aureus strains with varying vancomycin susceptibilities were us

SUBMITTER: Chang SC 

PROVIDER: S-EPMC10580833 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature