PM_2.5 induced neurotoxicity through unbalancing vitamin B12 metabolism by gut microbiota disturbance.

ABSTRACT: Fine particulate matter (PM_2.5) in the atmosphere is easily accompanied by toxic and harmful substances, causing serious harm to human health, including cognitive impairment. Vitamin B12 (VitB12) is an essential micronutrient that is synthesized by bacteria and contributes to neurotransmitter synthesis as a nutrition and signaling molecule. However, the relationship between VitB12 attenuation of cognitive impairment and intestinal microbiota regulation in PM_2.5 exposure has not been elucidated. In this study, we demonstrated that PM_2.5 caused behavioral defects and neuronal damage in Caenorhabditis elegans (C. elegans), along with significant gene expression changes in neurotransmitter receptors and a decrease in VitB12 content, causing behavi

SUBMITTER: Zhu X 

PROVIDER: S-EPMC10580859 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature