Inactivation of the Sts enzymes promotes resistance to lethal Staphylococcus aureus infection.

ABSTRACT: Staphylococcus aureus is a highly infective Gram-positive bacterial pathogen that causes a wide range of diseases in both healthy and immunocompromised individuals. It can evade host immune defenses by expressing numerous virulence factors and toxins. Coupled with the inability of the human host to develop protective immunity against S. aureus, the emergence of antibiotic-resistant strains complicates treatment options. The non-canonical Sts phosphatases negatively regulate signaling pathways in varied immune cell types. To determine the role of the Sts proteins in regulating host responses to a Gram-positive microorganism, we investigated the response of mice lacking Sts expression to S. aureus infection. Herein, we demonstrate that Sts ^-/- animals a

SUBMITTER: Zaman A 

PROVIDER: S-EPMC10580875 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature