The distinct transcriptome of virulence-associated phylogenetic group B2 Escherichia coli.

ABSTRACT: Escherichia coli strains of phylogenetic group B2 are often associated with urinary tract infections (UTIs) and several other diseases. Recent genomic and transcriptomic analyses have not suggested or identified specific genes required for virulence, but have instead suggested multiple virulence strategies and complex host-pathogen interactions. Previous analyses have not compared core gene expression between phylogenetic groups or between pathogens and nonpathogens within phylogenetic groups. We compared the core gene expression of 35 strains from three phylogenetic groups that included both pathogens and nonpathogens after growth in a medium that allowed comparable growth of both types of strains. K-means clustering suggested a B2 cluster with 17 group B2 strains and two group A s

SUBMITTER: Hogins J 

PROVIDER: S-EPMC10580932 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature