Delayed host mortality and immune response upon infection with P. aeruginosa persister cells.

ABSTRACT: Chronic infections are a heavy burden on healthcare systems worldwide. Persister cells are thought to be largely responsible for chronic infection due to their tolerance to antimicrobials and recalcitrance to innate immunity factors. Pseudomonas aeruginosa is a common and clinically relevant pathogen that contains stereotypical persister cells. Despite their importance in chronic infection, there have been limited efforts to study persister cell infections in vivo. Drosophila melanogaster has a well-described innate immune response similar to that of vertebrates and is a good candidate for the development of an in vivo model of infection for persister cells. Similar to what is observed in other bacterial strains, in this work we found that infection with P. aerugino

SUBMITTER: Hastings CJ 

PROVIDER: S-EPMC10580972 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature