PeAP1-mediated oxidative stress response plays an important role in the growth and pathogenicity of Penicillium expansum.

ABSTRACT: Penicillium expansum is the causal agent of post-harvest blue mold in various fruits and serves as a model for understanding fungal pathogenicity and mycotoxin production. The relevance of oxidative stress response in the growth and virulence of P. expansum has been largely unexplored. Here, we identify the transcriptional factor PeAP1 as a regulator of oxidative stress response in P. expansum. Gene expression and protein abundance of PeAP1, as well as its nuclear localization, are specifically induced by H₂O₂. Deletion of PeAP1 results in increased sensitivity to H₂O₂, and PeAP1 mutants exhibit a variety of defects in hyphal growth and virulence. PeAP1 prevents the accumulation of both intracellular H₂

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10581040 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature