Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC10581112 | biostudies-literature | 2022 Jan-Dec
REPOSITORIES: biostudies-literature
Zhang Xiaoyu X Zou Meijaun M Wu Yuwei Y Jiang Danli D Wu Ting T Zhao Yihan Y Wu Di D Cui Jing J Li Gang G
American journal of Alzheimer's disease and other dementias 20220101
(Genome-wide Association Studies) GWAS have identified ∼42 late-onset Alzheimer's disease (LOAD)-associated loci, each of which contains multiple single nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD) and most of these SNPs are in the non-coding region of human genome. However, how these SNPs regulate risk gene expression remains unknown. In this work, by using a set of novel techniques, we identified 6 functional SNPs (fSNPs) rs9271198, rs9271200, rs9281945, rs9271243, and rs9271 ...[more]