Cx43-mediated hyphal folding counteracts phagosome integrity loss during fungal infection.

ABSTRACT: Phagolysosomes are crucial organelles during the elimination of pathogens by host cells. The maintenance of their membrane integrity is vital during stressful conditions, such as during Candida albicans infection. As the fungal hyphae grow, the phagolysosome membrane expands to ensure that the growing fungus remains entrapped. Additionally, actin structures surrounding the hyphae-containing phagosome were recently described to damage and constrain these pathogens inside the host vacuoles by inducing their folding. However, the molecular mechanism involved in the phagosome membrane adaptation during this extreme expansion process is still unclear. The main goal of this study was to unveil the interplay between phagosomal membrane integrity and folding capacity of C. albicans-i

SUBMITTER: Cristovao B 

PROVIDER: S-EPMC10581180 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature