Parallel evolution of linezolid-resistant <i>Staphylococcus aureus</i> in patients with cystic fibrosis.

ABSTRACT: Linezolid is an antibiotic used to treat serious Staphylococcus aureus infections. Resistance to linezolid is considered rare but could emerge with repeated dosing. We recently reported widespread prescription of linezolid for a cohort of patients with cystic fibrosis (CF). The goals of this study were to determine the incidence of linezolid-resistant methicillin-resistant Staphylococcus aureus (MRSA) in CF and identify molecular mechanisms for linezolid resistance. We identified patients who cultured S. aureus resistant to linezolid with minimum inhibitory concentration (MIC) >4 at the University of Iowa CF Center between 2008 and 2018. We obtained isolates from these patients and retested susceptibility to linezolid using broth microdilution. We used whole genome seq

SUBMITTER: Pitcher NJ 

PROVIDER: S-EPMC10581212 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature