Molecular characterization and comparison of bla _NDM-1-carrying and bla _NDM-5-harboring IncX3-type plasmids in carbapenem-resistant Klebsiella pneumoniae.

ABSTRACT: Carbapenem-resistant Klebsiella pneumoniae (CRKP), which harbors the bla _NDM plasmid, has been reported extensively and is considered a global threat clinically. However, characterization and comparisons of bla _NDM-1-carrying and bla _NDM-5-harboring IncX3-type plasmids in CRKP are lacking. Here, we systematically compared the differences in the characteristics, genetic backgrounds, transferability, and fitness costs between bla _NDM-1-carrying and bla _NDM-5-carrying plasmids in K. pneumoniae isolates. Fifteen NDM-producing CRKP isolates were recovered from 1376 CRKP isolates between 2019 and 2021, of which 4 were positive for bla _NDM-1 and 11 were positive for bla

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10581223 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature