Intermittent hypoxia protects against hypoxic-ischemic brain damage by inducing functional angiogenesis.

ABSTRACT: Ischemic stroke (IS) induces neurological damage due to cerebrovascular occlusion. Restoring blood perfusion to the ischemic brain area in a timely fashion is the most effective treatment strategy. Hypoxia is an effective way of restoring blood perfusion by improving cerebrovascular microcirculation, while the effect varies greatly depending on hypoxic mode. This study aimed to screen for the optimal hypoxic mode to improve cerebrovascular microcirculation and prevent IS. Here, we found that compared with continuous hypoxia (CH), intermittent hypoxia (IH) significantly improved cerebral blood flow and oxygen saturation in mice without causing neurological impairment. By analyzing cerebrovascular microcirculation from mice, we found that the IH mode (13%, 5*10) with 13% O₂, 5 min

SUBMITTER: Guan Y 

PROVIDER: S-EPMC10581229 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature