Inflammatory cell death induced by 5-aminolevulinic acid-photodynamic therapy initiates anticancer immunity.

ABSTRACT:

Background

Inflammatory cell death is a form of programmed cell death (PCD) that induces inflammatory mediators during the process. The production of inflammatory mediators during cell death is beneficial in standard cancer therapies as it can break the immune silence in cancers and induce anticancer immunity. Photodynamic therapy (PDT) is a cancer therapy with photosensitizer molecules and light sources to destroy cancer cells, which is currently used for treating different types of cancers in clinical settings. In this study, we investigated if PDT using 5-aminolevulinic (5-ALA-PDT) causes inflammatory cell death and, subsequently, increases the immunogenicity of cancer cells.

Methods

Mouse breast cancer (4T1) and human colon cancer (DLD-1) cells were treated with 5-ALA fo

SUBMITTER: Wang L 

PROVIDER: S-EPMC10581343 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature