Phthalate exposure in the neonatal intensive care unit is associated with development of bronchopulmonary dysplasia.

ABSTRACT:

Objective

Bronchopulmonary dysplasia (BPD) is a serious yet common morbidity of preterm birth. Although prior work suggests a possible role for phthalate exposure in the development of BPD, no study has rigorously evaluated this. Our objective was to determine whether hospital-based phthalate exposure is associated with the development of BPD and to identify developmental windows sensitive to exposure.

Study design

This is a prospective multicenter cohort study of 360 preterm infants born at 23-33 weeks gestation participating in the Developmental Impact of NICU Exposures (DINE) cohort. 939 urine specimens collected during the NICU stay were analyzed for biomarkers of phthalate exposure by liquid chromatography with tandem mass spectrometry. The modified Shennan definition w

SUBMITTER: Stroustrup A 

PROVIDER: S-EPMC10581357 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature