Unique Gene Expression Signature in Periadrenal Adipose Tissue Identifies a High Blood Pressure Group in Patients With Cushing Syndrome.

ABSTRACT:

Background

Cushing syndrome (CS) is a rare disease caused by excess cortisol levels with high cardiovascular morbidity and mortality. Hypertension in CS promotes hypercortisolism-associated cardiovascular events. Adipose tissue is a highly plastic tissue with most cell types strongly affected by the excess cortisol exposure. We hypothesized that the molecular and cellular changes of periadrenal adipose tissue in response to cortisol excess impact systemic blood pressure levels in patients with CS.

Methods

We investigated gene expression signatures in periadrenal adipose tissue from patients with adrenal CS collected during adrenal surgery.

Results

During active CS we observed a downregulation of gene programs associated with inflammation in periadrenal adipose tissue.

SUBMITTER: Stifel U 

PROVIDER: S-EPMC10581443 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature