Estimating the attributable fraction of mortality from acute respiratory distress syndrome to inform enrichment in future randomised clinical trials.

ABSTRACT:

Background

Efficiency of randomised clinical trials of acute respiratory distress syndrome (ARDS) depends on the fraction of deaths attributable to ARDS (AF_ARDS) to which interventions are targeted. Estimates of AF_ARDS in subpopulations of ARDS could improve design of ARDS trials.

Methods

We performed a matched case-control study using the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE cohort. Primary outcome was intensive care unit mortality. We used nearest neighbour propensity score matching without replacement to match ARDS to non-ARDS populations. We derived two separate AF_ARDS estimates by matching patients with ARDS to patients with non-acute hypoxaemic respiratory failure (non-AHRF) and t

SUBMITTER: Saha R 

PROVIDER: S-EPMC10581447 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature