The phenotypic and genotypic association of grip strength with frailty, physical performance and functional limitations over time in older adults.

ABSTRACT:

Objectives

To replicate the phenotypic associations of grip strength with frailty, physical performance and functional limitations in older adults for longer follow-up periods and to examine whether these associations are due to shared genetic factors.

Methods

In total 2,262 participants 55 years and older with follow-up data up to 23 years (Nobservations = 8,262) from the Longitudinal Aging Study Amsterdam were included. Weighted polygenic risk scores for grip strength (PRS-GS) were built using the genome-wide meta-analysis results from UK Biobank as reference. Grip strength was measured two times on each hand using a dynamometer. Frailty index (FI) and frailty phenotype were operationalised following standard procedures. Performance tests included a timed walk test, a repe

SUBMITTER: Stringa N 

PROVIDER: S-EPMC10581539 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature