Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer's disease.

ABSTRACT: Recent studies have demonstrated that neuroplasticity, such as synaptic plasticity and neurogenesis, exists throughout the normal lifespan but declines with age and is significantly impaired in individuals with Alzheimer's disease. Hence, promoting neuroplasticity may represent an effective strategy with which Alzheimer's disease can be alleviated. Due to their significant ability to self-renew, differentiate, and migrate, neural stem cells play an essential role in reversing synaptic and neuronal damage, reducing the pathology of Alzheimer's disease, including amyloid-β, tau protein, and neuroinflammation, and secreting neurotrophic factors and growth factors that are related to plasticity. These events can promote synaptic plasticity and neurogenesis to repair the microenvironment of the

SUBMITTER: Chang J 

PROVIDER: S-EPMC10581561 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature