Identification of CD133⁺ intercellsomes in intercellular communication to offset intracellular signal deficit.

ABSTRACT: CD133 (prominin 1) is widely viewed as a cancer stem cell marker in association with drug resistance and cancer recurrence. Herein, we report that with impaired RTK-Shp2-Ras-Erk signaling, heterogenous hepatocytes form clusters that manage to divide during mouse liver regeneration. These hepatocytes are characterized by upregulated CD133 while negative for other progenitor cell markers. Pharmaceutical inhibition of proliferative signaling also induced CD133 expression in various cancer cell types from multiple animal species, suggesting an inherent and common mechanism of stress response. Super-resolution and electron microscopy localize CD133 on intracellular vesicles that apparently migrate between cells, which we name 'intercellsome.' Isolated CD133⁺ intercellsomes are enrich

SUBMITTER: Kaneko K 

PROVIDER: S-EPMC10581692 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature