Stereotactic Radiosurgery Outcomes in Medically and Surgically Failed or Nonsurgical Candidates with Medically Failed Prolactinomas: A Systematic Review and Meta-Analysis.

ABSTRACT: Objective  Prolactinomas are treated with dopamine agonists (DAs) as first-line therapy and transsphenoidal surgery as an alternative approach for medically failed tumors. We sought to summarize the efficacy of stereotactic radiosurgery (SRS) in the medically and surgically failed prolactinomas as well as in nonsurgical candidates with medically failed prolactinomas by systematic review and meta-analysis. Method  A literature search was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses guideline. Results  A total of 11 articles (total N  = 709) met inclusion criteria. Thirty-three percent of patients were able to achieve endocrine remission at a mean follow-up of 54.2 ± 42.2 months with no association between stopping D

SUBMITTER: Yagnik KJ 

PROVIDER: S-EPMC10581828 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature