Prognostic value of pretreatment inflammatory markers in localised prostate cancer before radical prostatectomy.

ABSTRACT:

Purpose

There is growing evidence of an association between inflammatory processes and cancer development and progression. In different solid tumor entities, a pronounced inflammatory response is associated with worse oncological outcome. In this study, we aim to evaluate the prognostic role of clinically established pretreatment inflammatory markers in patients with localised prostate cancer (PCa) before radical prostatectomy (RP).

Methods

A total of 641 men met our inclusion criteria and were followed prospectively for a median of 2.85 years. Univariable logistic and Cox regression analysis were performed to analyse associations between preoperative inflammatory markers and tumor characteristics, and biochemical recurrence free survival (BRFS).

Results

Median age at

SUBMITTER: Grogg JB 

PROVIDER: S-EPMC10581955 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature