Association of pronounced elevation of NET formation and nucleosome biomarkers with mortality in patients with septic shock.

ABSTRACT:

Background

Understanding the mechanisms underlying immune dysregulation in sepsis is a major challenge in developing more individualized therapy, as early and persistent inflammation, as well as immunosuppression, play a significant role in pathophysiology. As part of the antimicrobial response, neutrophils can release extracellular traps (NETs) which neutralize and kill microorganisms. However, excessive NETs formation may also contribute to pathogenesis, tissue damage and organ dysfunction. Recently, a novel automated assay has been proposed for the routine measurement of nucleosomes H3.1 (fundamental units of chromatin) that are released during NETs formation. The aim of the present study was to measure nucleosome levels in 151 septic shock patients (according to sepsis-3 defini

SUBMITTER: Haem Rahimi M 

PROVIDER: S-EPMC10581968 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature