Effects of CPAP and FiO₂ on respiratory effort and lung stress in early COVID-19 pneumonia: a randomized, crossover study.

ABSTRACT:

Background

in COVID-19 acute respiratory failure, the effects of CPAP and FiO₂ on respiratory effort and lung stress are unclear. We hypothesize that, in the compliant lungs of early Sars-CoV-2 pneumonia, the application of positive pressure through Helmet-CPAP may not decrease respiratory effort, and rather worsen lung stress and oxygenation when compared to higher FiO₂ delivered via oxygen masks.

Methods

In this single-center (S.Luigi Gonzaga University-Hospital, Turin, Italy), randomized, crossover study, we included patients receiving Helmet-CPAP for early (< 48 h) COVID-19 pneumonia without additional cardiac or respiratory disease. Healthy subjects were included as controls. Participants were equipped with an esophageal catheter, a non-invasive ca

SUBMITTER: Giosa L 

PROVIDER: S-EPMC10581975 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature