Regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolism.

ABSTRACT: Aging is the basis for several unfavorable conditions, including cardiovascular diseases (CVDs). In this sense, regular physical activity (regular PA) has been proven to delay cellular aging and prevent endothelial dysfunction related to CVDs. Despite numerous studies involving athletes, little is known about cellular and molecular mechanisms of regular PA among master athletes. The present study aimed at evaluating the effects of regular PA on local microcirculatory functions in elderly athletes as compared to age-matched sedentary controls. Moreover, molecular/epigenetic mechanisms (nitric oxide, oxidative stress, PGC-1α, SIRT1 and miR29) were also assessed. The results of the present study showed that regular PA significantly increased local blood flow in post-ischemia and post-heating

SUBMITTER: Scarfo G 

PROVIDER: S-EPMC10582030 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature